Vitamins that may be helpful
People with low blood levels of
antioxidants and those who eat few antioxidant-rich fruits and vegetables have been reported to be at high risk for
cataracts.11 12
Vitamin B2 and vitamin B3 are needed to protect glutathione, an important antioxidant in the eye.
Vitamin B2 deficiency has been linked to cataracts.13 14 Older people
taking 3 mg of vitamin B2 and 40 mg of vitamin B3 per day were partly protected against
cataracts in one trial.15 However, the intake of vitamin B2 in China is relatively
low, and it is not clear whether supplementation would help prevent cataracts in populations
where vitamin B2 intake is higher.
The major antioxidants in the lens of the eye are vitamin C16 and glutathione (a molecule
composed of three amino acids).17
Vitamin C is needed to activate vitamin
E,18 which in turn activates glutathione. Both nutrients are important for
healthy vision. People who take multivitamins
or any supplements containing vitamins C or E for more than 10 years have been reported to
have a 60% lower risk of forming a cataract.19
Vitamin C levels in the eye decrease with age.20 However, supplementing with
vitamin C prevents this decrease21 and has been linked to a lower risk of
developing cataracts.22 23 Healthy people are more likely to take
vitamin C and vitamin E supplements than those with cataracts according to some,24
but not all,25 studies. Dietary vitamin C intake has not been consistently
associated with protection from cataracts.26 27 Nonetheless, because
people who supplement with vitamin C have developed far fewer cataracts in some
research,28 29 doctors often recommend 500 to 1,000 mg of vitamin C
supplementation as part of a cataract prevention program. The difference between successful
and unsuccessful trials may be tied to the length of time people actually supplement with
vitamin C. In one preliminary study, people taking vitamin C for at least ten years showed a
dramatic reduction in cataract risk, but those taking vitamin C for less than ten years showed
no evidence of protection at all.30
Low blood levels of vitamin E have been
linked to increased risk of forming cataracts.31 32 Dietary vitamin E
intake has not been consistently associated with protection from cataracts.33
34 Vitamin E supplements have been reported to protect against cataracts in
animals35 and people,36 though the evidence remains
inconsistent.37 In one trial, people who took vitamin E supplements had less than
half the risk of developing cataracts, compared with others in the five-year
study.38 Doctors typically recommend 400 IU of vitamin E per day as prevention.
Smaller amounts (approximately 50 IU per day) have been proven in double-blind research to
provide no protection.39
Some,40 but not all,41 studies have reported that people eating more
foods rich in beta-carotene had a lower the
risk of developing cataracts. Supplementation with synthetic beta-carotene has not been found
to reduce the risk of cataract formation.42 It remains unclear whether natural
beta-carotene from food or supplements would protect the eye or whether beta-carotene in food
is merely a marker for other protective factors in fruits and vegetables high in beta-carotene.
People who eat a lot of spinach and kale, which are high in lutein and zeaxanthin, carotenoids similar to
beta-carotene, have been reported to be at low risk for cataracts.43 44
Lutein, zeaxanthin, and beta-carotene offer the promise of protection because they are
antioxidants. It is quite possible, however, that lutein is more important than beta-carotene,
because lutein is found in the lens of the eye, while beta-carotene is not.45 In
one preliminary study, lutein and zeaxanthin were the only carotenoids associated with
protection from cataracts.46 People with the highest intake of lutein and
zeaxanthin were half as likely to develop cataracts as those with the lowest intake. In
another study, supplementation with 15 mg of lutein three times a week for one year
significantly improved visual function in a small group of people with age-related
cataracts.47
The flavonoidquercetin may also help by blocking sorbitol
accumulation in the eye.48 This may be especially helpful for people with diabetes, though no clinical trials have yet explored
whether quercetin actually prevents diabetic cataracts.
Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.
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